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Testing baby bottles for the presence of residual and migrated bisphenol A

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Abstract

Plastic made with bisphenol A (BPA) produces trans-generational changes in genes and behavior. It has been positively linked to obesity and thyroid dysfunction. This study aimed to detect the presence of BPA in polycarbonate plastic (PC) baby bottles. Fifteen PC baby bottles with a clear indication of BPA free/safe/clear were randomly selected. High-performance liquid chromatography (HPLC) tests were used to detect residual or migrating BPA post three stress tests. An estimated intake of BPA among children was calculated then compared to the universal tolerable daily intake (TDI). Around 27% of bottles had detectable amounts of residual BPA in the first test, 100% released migrating BPA in the second and third tests. A significant positive linear trend in migrated BPA levels was observed over the three consecutive tests P < 0.0001. Approximately 73.5% of the accounted variability in BPA levels was due to these stress tests P < 0.0001. Babies from 0 to 3 months are expected to consume 0.8 to 23.8% of their safe TDI of BPA just by using plastic bottles between the first time of usage and after 60 washes (estimated 15 to 20 days of usage). Although no bottles have shown a risk of BPA intake exceeding TDI, the combined use of BPA bottles with other plastic utensils might result in reaching it. It is advisable to refrain from using BPA-containing plastic bottles or be cautious about usage duration. Manufacturers should indicate a clear margin of usage duration. Four baby bottle brands showed the least BPA leaking (Baby King, Camera, Sweet Baby, and Farlin).

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References

  • Berthoud, B. (2014). The Precautionary Principle in EU Risk Regulation: A Matter of Priorities. Germany: Anchor Academic Publishing.

    Google Scholar 

  • Brede, C., Fjeldal, P., Skjevrak, I., & Herikstad, H. (2003). Increased migration levels of bisphenol A from polycarbonate baby bottles after dishwashing, boiling and brushing. Food Additives and Contaminants, 20(7), 684–689. https://doi.org/10.1080/0265203031000119061.

    Article  CAS  Google Scholar 

  • Calafat, A. M., Ye, X., Wong, L. Y., Reidy, J. A., & Needham, L. L. (2008). Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environmental Health Perspectives, 116(1), 39–44. https://doi.org/10.1289/ehp.10753.

    Article  CAS  Google Scholar 

  • Carwile, J. L., Luu, H. T., Bassett, L. S., Driscoll, D. A., Yuan, C., Chang, J. Y., Ye, X., Calafat, A. M., & Michels, K. B. (2009). Polycarbonate bottle use and urinary bisphenol a concentrations. Environmental Health Perspectives, 117(9), 1368–1372. https://doi.org/10.1289/ehp.0900604.

    Article  CAS  Google Scholar 

  • Clara Silvestre, S. C. (2016). Ecosustainable polymer nanomaterials for food packaging: innovative solutions, characterization needs, safety and environmental issues. UK: CRC Press Taylor & Francis Group.

    Google Scholar 

  • Crawley, H. (2011). Infant feeding: a resource for health care professionals and parents. London: Royal College of Midwives.

    Google Scholar 

  • Dornath, P. J. (2010). Analysis of chemical leaching from common consumer plastic bottles under high stress conditions. Oregon State University USA.

  • Edginton, A. N., & Ritter, L. (2009). Predicting plasma concentrations of bisphenol A in children younger than 2 years of age after typical feeding schedules, using a physiologically based toxicokinetic model. Environmental Health Perspectives, 117(4), 645–652. https://doi.org/10.1289/ehp.0800073.

    Article  CAS  Google Scholar 

  • Ehlert, K. A., Beumer, C. W., & Groot, M. C. (2008). Migration of bisphenol A into water from polycarbonate baby bottles during microwave heating. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 25(7), 904–910. https://doi.org/10.1080/02652030701867867.

    Article  CAS  Google Scholar 

  • European Food Safety, A. (2016). Guidance of the Scientific Panel of Food Contact Materials, Enzymes, Flavourings and Processing Aids on the submission of a dossier on food enzymes for safety evaluation by the Scientific Panel of Food Contact Materials, Enzymes, Flavourings and Processing Aids. Luxembourg: Publications Office.

  • Gould, J. C., Leonard, L. S., Maness, S. C., Wagner, B. L., Conner, K., Zacharewski, T., Safe, S., McDonnell, D. P., & Gaido, K. W. (1998). Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. Molecular and Cellular Endocrinology, 142(1–2), 203–214.

    Article  CAS  Google Scholar 

  • Government, A. (2010). Voluntary phase-out by major Australian retailers of polycarbonate plastic baby bottles containing BPA. http://www.foodstandards.gov.au/consumer/chemicals/bpa/pages/regulationandmonitor5377.aspx. Accessed 12 of FEB 2018.

  • Group, W. H. O. M. G. R. S. (2006). WHO Child Growth Standards based on length/height, weight and age. Acta Paediatrica. Supplement, 450, 76–85.

    Google Scholar 

  • Halden, R. U. (2010). Plastics and health risks. Annual Review of Public Health, 31, 179–194. https://doi.org/10.1146/annurev.publhealth.012809.103714.

    Article  Google Scholar 

  • Heimeier, R. A., Das, B., Buchholz, D. R., & Shi, Y. B. (2009). The xenoestrogen bisphenol A inhibits postembryonic vertebrate development by antagonizing gene regulation by thyroid hormone. Endocrinology, 150(6), 2964–2973. https://doi.org/10.1210/en.2008-1503.

    Article  CAS  Google Scholar 

  • Hester, S. N., Hustead, D. S., Mackey, A. D., Singhal, A., & Marriage, B. J. (2012). Is the macronutrient intake of formula-fed infants greater than breast-fed infants in early infancy? J Nutr Metab, 2012, 1–13. https://doi.org/10.1155/2012/891201.

    Article  CAS  Google Scholar 

  • Joint, F. A. O. W. H. O. E. M., Bisphenol, a., World Health, O., Food, & Agriculture Organization of the United, N. (2011). Toxicological and health aspects of bisphenol A: report of joint FAO/WHO Expert Meeting 2–5 November 2010 and report of stakeholder meeting on bisphenol A, 1 November 2010, Ottawa, Canada.

  • Kubwabo, C., Kosarac, I., Stewart, B., Gauthier, B. R., Lalonde, K., & Lalonde, P. J. (2009). Migration of bisphenol A from plastic baby bottles, baby bottle liners and reusable polycarbonate drinking bottles. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 26(6), 928–937. https://doi.org/10.1080/02652030802706725.

    Article  CAS  Google Scholar 

  • Kuroda, N., Kinoshita, Y., Sun, Y., Wada, M., Kishikawa, N., Nakashima, K., Makino, T., & Nakazawa, H. (2003). Measurement of bisphenol A levels in human blood serum and ascitic fluid by HPLC using a fluorescent labeling reagent. Journal of Pharmaceutical and Biomedical Analysis, 30(6), 1743–1749.

    Article  CAS  Google Scholar 

  • Lan, H. C., Lin, I. W., Yang, Z. J., & Lin, J. H. (2015). Low-dose bisphenol A activates Cyp11a1 gene expression and corticosterone secretion in adrenal gland via the JNK signaling pathway. Toxicological Sciences, 148(1), 26–34. https://doi.org/10.1093/toxsci/kfv162.

    Article  CAS  Google Scholar 

  • Lateef, S. S. (2017). Analysis of bisphenol A leaching from baby feeding bottles. Agilent, 11.

  • Laws, S. C., Carey, S. A., Ferrell, J. M., Bodman, G. J., & Cooper, R. L. (2000). Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Toxicological Sciences, 54(1), 154–167.

    Article  CAS  Google Scholar 

  • Maragou, N. C., Makri, A., Lampi, E. N., Thomaidis, N. S., & Koupparis, M. A. (2008). Migration of bisphenol A from polycarbonate baby bottles under real use conditions. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 25(3), 373–383. https://doi.org/10.1080/02652030701509998.

    Article  CAS  Google Scholar 

  • Nam, S. H., Seo, Y. M., & Kim, M. G. (2010). Bisphenol A migration from polycarbonate baby bottle with repeated use. Chemosphere, 79(9), 949–952. https://doi.org/10.1016/j.chemosphere.2010.02.049.

    Article  CAS  Google Scholar 

  • Oehlmann, J., Schulte-Oehlmann, U., Kloas, W., Jagnytsch, O., Lutz, I., Kusk, K. O., Wollenberger, L., Santos, E. M., Paull, G. C., van Look, K. J. W., & Tyler, C. R. (2009). A critical analysis of the biological impacts of plasticizers on wildlife. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 364(1526), 2047–2062. https://doi.org/10.1098/rstb.2008.0242.

    Article  CAS  Google Scholar 

  • Pjanic, M. (2017). The role of polycarbonate monomer bisphenol-A in insulin resistance. PeerJ, 5, e3809. https://doi.org/10.7717/peerj.3809.

    Article  CAS  Google Scholar 

  • Recchia, A. G., Vivacqua, A., Gabriele, S., Carpino, A., Fasanella, G., Rago, V., Bonofiglio, D., & Maggiolini, M. (2004). Xenoestrogens and the induction of proliferative effects in breast cancer cells via direct activation of oestrogen receptor alpha. Food Additives and Contaminants, 21(2), 134–144. https://doi.org/10.1080/02652030310001641177.

    Article  CAS  Google Scholar 

  • Royal College of, N. (2007). Formula feeds : RCN guidance for nurses caring for infants and mothers. (3rd edition ed.). London: Royal College of Nursing, London : [distributor] Royal College of Nursing, London. 

  • Schierow, L. J. (2011). Bisphenol A (BPA) in Plastics and Possible Human Health Effects. USA: DIANE Publishing Company.

  • ​Bolognesi, C., Castle, L., Cravedi, J.-P., Engel, K.-H., Fowler, P., Franz, R., et al. (2015). Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs. EFSA Journal, 13(1).

  • Shmarakov, I. O., Borschovetska, V. L., & Blaner, W. S. (2017). Hepatic detoxification of bisphenol A is retinoid-dependent. Toxicological Sciences, 157(1), 141–155. https://doi.org/10.1093/toxsci/kfx022.

    Article  CAS  Google Scholar 

  • Stevens, E. E., Patrick, T. E., & Pickler, R. (2009). A history of infant feeding. The Journal of Perinatal Education, 18(2), 32–39. https://doi.org/10.1624/105812409X426314.

    Article  Google Scholar 

  • Stoker, T. E., Robinette, C. L., Britt, B. H., Laws, S. C., & Cooper, R. L. (1999). Prepubertal exposure to compounds that increase prolactin secretion in the male rat: effects on the adult prostate. Biology of Reproduction, 61(6), 1636–1643.

    Article  CAS  Google Scholar 

  • Sun, Y., Irie, M., Kishikawa, N., Wada, M., Kuroda, N., & Nakashima, K. (2004). Determination of bisphenol A in human breast milk by HPLC with column-switching and fluorescence detection. Biomedical Chromatography, 18(8), 501–507. https://doi.org/10.1002/bmc.345.

    Article  CAS  Google Scholar 

  • Tan, B. L., & Mustafa, A. M. (2003). Leaching of bisphenol A from new and old babies’ bottles, and new babies’ feeding teats. Asia-Pacific Journal of Public Health, 15(2), 118–123. https://doi.org/10.1177/101053950301500208.

    Article  CAS  Google Scholar 

  • Tripathi, G. (2010). Cellular and Biochemical Science. India: I.K. International Publishing House Pvt. Limited.

  • Vandenberg, L. N., Chahoud, I., Heindel, J. J., Padmanabhan, V., Paumgartten, F. J., & Schoenfelder, G. (2012). Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Ciência & Saúde Coletiva, 17(2), 407–434.

    Article  Google Scholar 

  • Wang, T., Li, M., Chen, B., Xu, M., Xu, Y., Huang, Y., Lu, J., Chen, Y., Wang, W., Li, X., Liu, Y., Bi, Y., Lai, S., & Ning, G. (2012). Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance. The Journal of Clinical Endocrinology and Metabolism, 97(2), E223–E227. https://doi.org/10.1210/jc.2011-1989.

    Article  CAS  Google Scholar 

  • Washam, C. (2006). Exploring the roots of diabetes: bisphenol A may promote insulin resistance. Environmental Health Perspectives, 114(1), A48–A49.

    Article  Google Scholar 

  • Williams, C., Bondesson, M., Krementsov, D. N., & Teuscher, C. (2014). Gestational bisphenol A exposure and testis development. Endocr Disruptors (Austin), 2(1), e29088. https://doi.org/10.4161/endo.29088.

    Article  Google Scholar 

  • Wolstenholme, J. T., Edwards, M., Shetty, S. R., Gatewood, J. D., Taylor, J. A., Rissman, E. F., et al. (2012). Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression. Endocrinology, 153(8), 3828–3838. https://doi.org/10.1210/en.2012-1195.

    Article  CAS  Google Scholar 

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Correspondence to Nedal Al-Rawashdeh.

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Ali, M., Jaghbir, M., Salam, M. et al. Testing baby bottles for the presence of residual and migrated bisphenol A. Environ Monit Assess 191, 7 (2019). https://doi.org/10.1007/s10661-018-7126-0

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